1duw: Difference between revisions
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'''STRUCTURE OF NONAHEME CYTOCHROME C''' | {{Structure | ||
|PDB= 1duw |SIZE=350|CAPTION= <scene name='initialview01'>1duw</scene>, resolution 1.89Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''STRUCTURE OF NONAHEME CYTOCHROME C''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1DUW is a [ | 1DUW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_desulfuricans Desulfovibrio desulfuricans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUW OCA]. | ||
==Reference== | ==Reference== | ||
Three-dimensional structure of the nonaheme cytochrome c from Desulfovibrio desulfuricans Essex in the Fe(III) state at 1.89 A resolution., Umhau S, Fritz G, Diederichs K, Breed J, Welte W, Kroneck PM, Biochemistry. 2001 Feb 6;40(5):1308-16. PMID:[http:// | Three-dimensional structure of the nonaheme cytochrome c from Desulfovibrio desulfuricans Essex in the Fe(III) state at 1.89 A resolution., Umhau S, Fritz G, Diederichs K, Breed J, Welte W, Kroneck PM, Biochemistry. 2001 Feb 6;40(5):1308-16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11170457 11170457] | ||
[[Category: Desulfovibrio desulfuricans]] | [[Category: Desulfovibrio desulfuricans]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: hydrogenase]] | [[Category: hydrogenase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:44:46 2008'' | ||
Revision as of 11:44, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF NONAHEME CYTOCHROME C
OverviewOverview
A nine heme group containing cytochrome c isolated from the soluble and membrane fractions of Desulfovibrio desulfuricans Essex, termed nonaheme cytochrome c, was crystallized, and the structure was solved using the multiple wavelength anomalous dispersion (MAD) phasing method. Refinement was carried out to a resolution of 1.89 A, and anisotropic temperature factors were addressed to the iron and sulfur atoms in the model. The structure revealed two cytochrome c(3) like domains with the typical arrangement of four heme centers. Both domains flanked an extra heme buried under the protein surface. This heme is held in position by loop extensions in each of the two domains. Although both the N- and C-terminal tetraheme domains exhibit a fold and heme arrangement very similar to that of cytochrome c(3), they differ considerably in their loop extensions and electrostatic surface. Analysis of the structure provides evidence for a different function of both domains, namely, anchoring the protein in a transmembranous complex with the N-terminal domain and formation of an electron-transfer complex with hydrogenase by the C-terminal domain.
About this StructureAbout this Structure
1DUW is a Single protein structure of sequence from Desulfovibrio desulfuricans. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of the nonaheme cytochrome c from Desulfovibrio desulfuricans Essex in the Fe(III) state at 1.89 A resolution., Umhau S, Fritz G, Diederichs K, Breed J, Welte W, Kroneck PM, Biochemistry. 2001 Feb 6;40(5):1308-16. PMID:11170457
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