Vinculin: Difference between revisions
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{{STRUCTURE_1st6| PDB=1st6 | SIZE=400| SCENE= |right|CAPTION=Chicken full-length metavinculin, [[1st6]] }} | {{STRUCTURE_1st6| PDB=1st6 | SIZE=400| SCENE= |right|CAPTION=Chicken full-length metavinculin, [[1st6]] }} | ||
[[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, ''i.e.'' crystal structure of human full-length Vinculin ([[1tr2]]). <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | [[Vinculin|Vinculins]] (VCLs) are involved in adhesion by linking integrin molecules to the actin cytoskeleton. Its head domain (Vd1) can bind to [[Talin|talin]] or to [[Actinin|alpha-actinin]] at their respective VCL Binding Sites (VBS). A splice variant of vinculin is meta-vinculin (m-VCL). The protein raver1 RNA Recognition Motif (RRM) forms a complex with VCL or m-VCL. The images at the left and at the right correspond to one representative Vinculin structure, ''i.e.'' crystal structure of human full-length Vinculin ([[1tr2]]). <scene name='Sandbox_27/Role_i997_vinculin_head-tail_1/1'>Vinculin Autoinhibition</scene> is achieved through a high affinity intramolecular interaction between tail (orange) and head (aqua) domains ([[1st6]]). Energetically, I997 is key to maintaining this autoinhibition. | ||
== 3D Structures of Vinculin == | == 3D Structures of Vinculin == | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
===Vinculin=== | |||
[[3h2u]] – hVCL Vd1 + raver1 RRM - human<br /> | [[3h2u]] – hVCL Vd1 + raver1 RRM - human<br /> | ||
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[[3zdl]] – cVCL Vd1 + amyloid β precursor protein N terminal<br /> | [[3zdl]] – cVCL Vd1 + amyloid β precursor protein N terminal<br /> | ||
==Metavinculin== | ===Metavinculin=== | ||
[[3myi]] – m-VCL tail domain <br /> | [[3myi]] – m-VCL tail domain <br /> | ||