Toll-like Receptors: Difference between revisions
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'''Toll-like receptors''', often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]]. | '''Toll-like receptors''', often abbreviated TLRs, are found on the surface of phagocytic cells of vertebrates and invertebrates and are critical to the innate immune system. The Toll-like receptors recognize molecular patterns associated with pathogens, such as double-stranded RNA, lipopolysaccharide, or CpG DNA, and initiate an intracellular kinase cascade, inducing an immediate defensive response.<ref>PMID: 20084417</ref><ref>PMID: 18064347</ref> The receptors are multi-domain structures consisting of an extracellular ectodomain, a transmembrane domain and a intracellular Toll/IL-1 receptor domain. The extracellular domains contain [[leucine-rich repeats]]. | ||
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Articles in Proteopedia concerning Toll-like Receptors include: | Articles in Proteopedia concerning Toll-like Receptors include: | ||
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*[[:Category:Toll like receptor adaptor domain|Toll like receptor adaptor domain]] | *[[:Category:Toll like receptor adaptor domain|Toll like receptor adaptor domain]] | ||
*[[:Category:Tlr|TLR]] | *[[:Category:Tlr|TLR]] | ||
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{{STRUCTURE_3ciy| PDB=3ciy | SIZE=400| SCENE=Toll-like_Receptors/3ciynice/1 |right|CAPTION=Glycosylated mouse toll-like receptor 3 dimer complex with double-stranded RNA [[3ciy]] }} | {{STRUCTURE_3ciy| PDB=3ciy | SIZE=400| SCENE=Toll-like_Receptors/3ciynice/1 |right|CAPTION=Glycosylated mouse toll-like receptor 3 dimer complex with double-stranded RNA [[3ciy]] }} | ||
==3D Structures of Toll-like Receptors== | ==3D Structures of Toll-like Receptors== | ||