Ribonucleotide reductase: Difference between revisions
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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }} | {{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }} | ||
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. | '''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.<br /> | ||
* '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.<br /> | |||
* ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br /> | |||
* '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center.<br /> | |||
For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]]. | |||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
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[[4n82]] – SsRNR – ''Streptococcus sanguinis''<br /> | [[4n82]] – SsRNR – ''Streptococcus sanguinis''<br /> | ||
''RNR large subunit complex'' | |||
[[3hnc]] – hRNR M1 + TTP – human<BR /> | [[3hnc]] – hRNR M1 + TTP – human<BR /> | ||
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[[4n83]] - SsRNR + Mn<br /> | [[4n83]] - SsRNR + Mn<br /> | ||
''RNR small subunit complex'' | |||
[[1rsr]], [[1rsv]] - EcRNR R2 (mutant) + N3<BR /> | [[1rsr]], [[1rsv]] - EcRNR R2 (mutant) + N3<BR /> | ||