Peroxiredoxin

Peroxiredoxin (Prx) is an antioxidant enzyme. In the Prxs the active-site Cys is oxidized to sulfenic acid byperoxide. The Prxs are divided into typical 2-Cys Prx, atypical 2-Cys Prx and 1-Cys Prx. Prx 5 is expressed in mammalian tissue. The images at the left and at the right correspond to one representative Prx, i.e. the crystal structure of Peroxiredoxin from rat (1qq2).

3D Structures of Peroxiredoxin3D Structures of Peroxiredoxin

Updated on 19-August-2014

1qq2 – r2Cys-Prx – rat
2c0d – Pf2Cys-Prx – Plasmodium falciparum
1xiy – Pf1Cys-Prx
1xcc, 2h01, 3tb2 - 1Cys-Prx – Plasmodium yoelii
2i81 - 2Cys-Prx – Plasmodium vivax
1qmv - h2Cys-Prx – human
3cmi – yPrx hyr1 - yeast
4g2e – Prx – Sulfolobus tokodaii
3sbc – yPrx Tsa1 (mutant)
1uul - 2Cys-Prx – Trypanosoma cruzi
1we0 – Prx – Amphibacillus xylanus
2cv4, 2cx3, 2cx4 – Prx – Aeropyrum pernix
3drn – SsPrx – Sulfolobus solfataricus
3hjp – SsPrx (mutant)
3ixr – Prx PRXQ (mutant) – Xylella fastidiosa

Peroxiredoxin 1Peroxiredoxin 1

2rii, 3hy2 – hPrx 1 (mutant)+sulfiredoxin 1
2z9s – rPrx 1 (mutant)
4kw6, 4fh8 – Prx 1 – Ancylostoma ceylanicum
3zl5 - mPrx 1 (mutant) – mouse

Peroxiredoxin 2Peroxiredoxin 2

1tp9 – Prx II – Populus trichocarpa
2pwj – Prx II – garden pea
4dsq, 4dsr, 4h86 – yPrx II
4dss – yPrx II (mutant) + thioredoxin II

Peroxiredoxin 3Peroxiredoxin 3

1zye – Prx III (mutant) – bovine

Peroxiredoxin 4Peroxiredoxin 4

3tjf, 3tjg, 3tjj, 3tjk, 3tkr - hPrx 4 (mutant)
3qpm – Prx 4 – Larimichtys crocea
2pn8, 3tjb, 3tkp, 3tkq, 3tks – hPrx 4
3vwu, 3vwv - mPrx 4 (mutant)

Peroxiredoxin 5Peroxiredoxin 5

1urm – hPrx 5 (mutant) – human
2vl2, 2vl3, 2vl9, 1h4o, 1hd2, 1oc3 – hPrx 5
3mng – hPrx 5+DTT
2wfc – lPrx 5 - lugworm
2xhf – Prx 5 – Alvinella pompejana

Peroxiredoxin 6Peroxiredoxin 6

2v2g – lPrx 6
2v32, 2v41 – lPrx 6 (mutant)