Fibronectin: Difference between revisions
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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | ||
{{STRUCTURE_3m7p| PDB=3m7p | SIZE=400| SCENE= |right|CAPTION=Human fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions [[3m7p]] }} | {{STRUCTURE_3m7p| PDB=3m7p | SIZE=400| SCENE= |right|CAPTION=Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) [[3m7p]] }} | ||
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[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | [[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | ||
== 3D Structures of Fibronectin == | == 3D Structures of Fibronectin == | ||
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[[2fn2]] – hFn 2FnII – NMR | [[2fn2]] – hFn 2FnII – NMR | ||
=== Fn module FnIII === | === Fn module FnIII === | ||
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[[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br /> | [[1mfn]], [[2mfn]] – Fn 9-10FnIII – mouse - NMR<br /> | ||
[[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens'' | [[2vmg]], [[2vmi]] - Fn FnIII carbohydrate-binding domain – ''Clostridium perfringens'' | ||
=== Fn module FnI+FnII === | === Fn module FnI+FnII === | ||
Revision as of 11:30, 18 August 2014
Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, i.e. the crystal structure of human Fibronectin 4-5FnI fragment (1fbr).
3D Structures of Fibronectin3D Structures of Fibronectin
Updated on 18-August-2014
Fn module FnIFn module FnI
3m7p – hFn GBD – human
1e8b, 1e88, 1qo6 - hFn GBD – NMR
3gxe, 3ejh – hFn 8-9FnI+collagen alpha-1
1fbr - hFn 4-5FnI - NMR
2rky, 2rl0 – hFn 4-5FnI+Fn binding peptide
2rkz, 3cal, 3zrz - hFn 2-3FnI+Fn binding peptide
2cg6, 2cg7 - hFn 2-3FnI
2cku - hFn 2-3FnI – NMR
1o9a - hFn 1-2FnI+B3 from FNBB – NMR
2ec3 – hFn 11FnI – NMR
3r8q – hFn 12-14FnI
1qgb – hFn FnI N-terminal - NMR
2ck2 – hFn (mutant) core swapped
1j8k – hFn extra domain 2 – NMR
1fnh – hFn heparin and integrin binding domains
2qbw, 3ch8 – hFn-PDZ fusion
4gh7 – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
Fn module FnIIFn module FnII
2fn2 – hFn 2FnII – NMR
Fn module FnIIIFn module FnIII
1q38, 1x3d, 1x4x, 1x5x - hFn FnIII – NMR
2h41, 2h45 – hFn 2FnIII – NMR
1oww - hFn 1FnIII – NMR
2ha1 - hFn 1-2FnIII – NMR
2crm - hFn 4FnIII – NMR
2crz - hFn 5FnIII – NMR
1fna, 1ttf, 1ttg – hFn 10FnIII
2ocf - hFn 10FnIII+estrogen receptor ligand-binding domain
1fnf – hFn 7-10FnIII
2fnb – hFn FnIII ed-b domain – NMR
1mfn, 2mfn – Fn 9-10FnIII – mouse - NMR
2vmg, 2vmi - Fn FnIII carbohydrate-binding domain – Clostridium perfringens
Fn module FnI+FnIIFn module FnI+FnII
3mql – hFn 6FnI+2FnII+7FnI