Cadherin: Difference between revisions

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[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.  Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons).  The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, ''i.e.'' the crystal structure of Cadherin ([[1q1p]]).  Calcium ions is shown as a space filling objects.
[[Cadherin|Cadherins]] (CDH) are calcium-dependent adhesion proteins.  They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions.  They are encoded by numerous genes numbered CDH1-CDH23.  Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons).  The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, ''i.e.'' the crystal structure of Cadherin ([[1q1p]]).  Calcium ions is shown as a space filling objects.
__NOTOC__


== 3D Structures of Cadherin ==
== 3D Structures of Cadherin ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


=== CDH encoded by CDH1 ===
=== CDH1 ===


[[1q1p]] – mCDH1 - mouse<br />
[[1q1p]] – mCDH1 - mouse<br />
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[[3qrb]] – mCDH1+2
[[3qrb]] – mCDH1+2


=== CDH encoded by CDH5 ===
=== CDH5 ===


[[2koh]] – mCDH5+PAR3-PDZ3<br />
[[2koh]] – mCDH5+PAR3-PDZ3<br />


=== CDH encoded by CDH6 ===
=== CDH6 ===


[[3lnd]] – mCDH6 EC12 (mutant)<br />
[[3lnd]] – mCDH6 EC12 (mutant)<br />


=== CDH encoded by CDH8 ===
=== CDH8 ===


[[1zxk]] – mCDH8 EC1<br />
[[1zxk]] – mCDH8 EC1<br />
[[2a62]] - mCDH8 EC1+EC2+EC3<br />
[[2a62]] - mCDH8 EC1+EC2+EC3<br />


=== CDH encoded by CDH11 ===
=== CDH11 ===


[[2a4c]], [[2a4e]] – mCDH11 EC1<br />
[[2a4c]], [[2a4e]] – mCDH11 EC1<br />


=== CDH encoded by CDH20 ===
=== CDH20 ===


[[1zvn]] – cCDH20 EC1 – chicken<br />
[[1zvn]] – cCDH20 EC1 – chicken<br />


=== CDH encoded by CDH23 ===
=== CDH23 ===


[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />  
[[3mvs]], [[2whv]] – mCDH23 N-terminal<br />  
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[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
[[2omt]], [[2omu]], [[2omx]], [[2omz]], [[2omv]], [[2omw]], [[2omy]] – hE-CDH EC1+internalin (mutant)<br />
[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />
[[1o6s]] – E-CDH N-terminal+internalin – ''Listeria monocytogenes''<br />


=== T-CDH membrane bound ===
=== T-CDH membrane bound ===


[[3k5r]] – mT-CDH EC1+EC2<br />
[[3k5r]] – mT-CDH EC1+EC2<br />
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[[3k6i]] - cT-CDH EC1<br />
[[3k6i]] - cT-CDH EC1<br />
[[2v37]] – hT-CDH N-terminal - NMR<br />
[[2v37]] – hT-CDH N-terminal - NMR<br />


=== N-CDH neuronal ===
=== N-CDH neuronal ===


[[1nch]], [[1nci]] – mN-CDH<br />
[[1nch]], [[1nci]] – mN-CDH<br />
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=== Protocadherin ===
=== Protocadherin ===


[[2yst]] – hProt-CDH7 EC3 – NMR<br />
[[2yst]] – hProt-CDH7 EC3 – NMR<br />
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=== Desmoglein ===
=== Desmoglein ===


[[2yqg]] – hDes-CDH EC1<br />
[[2yqg]] – hDes-CDH EC1<br />


[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:37, 17 August 2014

File:1q1p.png
Crystal Structure of Cadherin, 1q1p

Template:STRUCTURE 1q1p
















Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, i.e. the crystal structure of Cadherin (1q1p). Calcium ions is shown as a space filling objects.

3D Structures of Cadherin3D Structures of Cadherin

Updated on 17-August-2014

CDH1CDH1

1q1p – mCDH1 - mouse
3q2v – mCDH1 ectodomain
3qrb – mCDH1+2

CDH5CDH5

2koh – mCDH5+PAR3-PDZ3

CDH6CDH6

3lnd – mCDH6 EC12 (mutant)

CDH8CDH8

1zxk – mCDH8 EC1
2a62 - mCDH8 EC1+EC2+EC3

CDH11CDH11

2a4c, 2a4e – mCDH11 EC1

CDH20CDH20

1zvn – cCDH20 EC1 – chicken

CDH23CDH23

3mvs, 2whv – mCDH23 N-terminal
2kbr – hCDH23 peptide+harmonin – NMR - human
2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR
2wbx – mCDH23 EC1
2wcp - mCDH23 EC2
2wd0 - mCDH23 EC1+EC2 (mutant)
4apx, 4aq8, 4axw - mCDH23 EC1+EC2 + Pro-CDH15
4aqa, 4aqe - mCDH23 EC1+EC2 (mutant) + Pro-CDH15

C-CDH “classical”C-CDH “classical”

1l3w – XlC-CDH ectodomain - Xenopus laevis
1q5b, 1q5c, 1q55, 1q5a – C-CDH model into desmosome – electron tomography

E-CDH epithelialE-CDH epithelial

1ff5 – mE-CDH double domain
1edh - mE-CDH EC1+EC2+Ca
3q2l, 3q2n - mE-CDH EC1+EC2 (mutant)
1suh – mE-CDH N-terminal - NMR
3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin
3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant)
2qvf – mE-CDH1 CDH2
3ifq – hE-CDH EC1+EC2+EC3
2o72 - hE-CDH EC1+EC2
3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor
2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)
1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes

T-CDH membrane boundT-CDH membrane bound

3k5r – mT-CDH EC1+EC2
3k5s - cT-CDH EC1+EC2
3k6d - XlT-CDH EC1
3k6f - mT-CDH EC1
3k6i - cT-CDH EC1
2v37 – hT-CDH N-terminal - NMR

N-CDH neuronalN-CDH neuronal

1nch, 1nci – mN-CDH
1ncg – mN-CDH (mutant)
2qvi – mN-CDH EC12
1ncj – mN-CDH two domains
3q2w – mN-CDH ectodomain
1op4 - mN-CDH prodomain - NMR
3ubf – DmN-CDH ectodomain – Drosophila melanogaster
3ubh - DmN-CDH EC1-4
3ubg - DmN-CDH EC1-

VE-CDH vascular epithelialVE-CDH vascular epithelial

3ppe – cVE-CDH EC1+EC2

ProtocadherinProtocadherin

2yst – hProt-CDH7 EC3 – NMR
2ee0 - hProt-CDH9 Ca domain – NMR
1wyj - mProt-CDH β 14 - NMR
1wuz - mProt-CDH4 EC1 – NMR

DesmogleinDesmoglein

2yqg – hDes-CDH EC1

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel
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