4uuv: Difference between revisions

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'''Unreleased structure'''
==Structure of the DNA binding ETS domain of human ETV4 in complex with DNA==
 
<StructureSection load='4uuv' size='340' side='right' caption='[[4uuv]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
The entry 4uuv is ON HOLD  until sometime in the future
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4uuv]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UUV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UUV FirstGlance]. <br>
Authors: Newman, J.A., Cooper, C.D.O., Kopec, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Gileadi, O.
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uuv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uuv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uuv RCSB], [http://www.ebi.ac.uk/pdbsum/4uuv PDBsum]</span></td></tr>
 
<table>
Description: Structure of the DNA binding ETS domain of human ETV4 in complex with DNA
== Disease ==
[[http://www.uniprot.org/uniprot/ETV4_HUMAN ETV4_HUMAN]] Ewing sarcoma. 
== Function ==
[[http://www.uniprot.org/uniprot/ETV4_HUMAN ETV4_HUMAN]] Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.<ref>PMID:19307308</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Cooper, C D.O.]]
[[Category: Delft, F von.]]
[[Category: Edwards, A M.]]
[[Category: Gileadi, O.]]
[[Category: Kopec, J.]]
[[Category: Newman, J A.]]
[[Category: Transcription]]

Revision as of 12:22, 13 August 2014

Structure of the DNA binding ETS domain of human ETV4 in complex with DNAStructure of the DNA binding ETS domain of human ETV4 in complex with DNA

Structural highlights

4uuv is a 24 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[ETV4_HUMAN] Ewing sarcoma.

Function

[ETV4_HUMAN] Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.[1]

References

  1. ↑ Guo B, Sharrocks AD. Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. Mol Cell Biol. 2009 Jun;29(11):3204-18. doi: 10.1128/MCB.01128-08. Epub 2009 Mar , 23. PMID:19307308 doi:http://dx.doi.org/10.1128/MCB.01128-08

4uuv, resolution 2.80Å

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