1dfq: Difference between revisions

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Revision as of 11:37, 20 March 2008

File:1dfq.gif

, resolution 2.60Å

Ligands:

Activity:

Tentoxilysin, with EC number 3.4.24.68

Coordinates:

save as pdb, mmCIF, xml

THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID

OverviewOverview

The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.

About this StructureAbout this Structure

1DFQ is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

ReferenceReference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735

Page seeded by OCA on Thu Mar 20 10:37:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1dfq.gif|left|200px]]<br /><applet load="1dfq" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1dfq.gif|left|200px]]
-caption="1dfq, resolution 2.60&Aring;" />
-'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID'''<br />
+ {{Structure
+|PDB= 1dfq |SIZE=350|CAPTION= <scene name='initialview01'>1dfq</scene>, resolution 2.60&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SLB:5-N-ACETYL-BETA-D-NEURAMINIC ACID'>SLB</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68]
+|GENE=
+}}
+'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH SIALIC ACID'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-DFQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=SLB:'>SLB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tentoxilysin Tentoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.68 3.4.24.68] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA].
+DFQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DFQ OCA].
 ==Reference==
-The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10722735 10722735]
+The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10722735 10722735]
 [[Category: Clostridium tetani]]
 [[Category: Single protein]]
@@ Line 28: / Line 37: @@
 [[Category: toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:16:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:37:55 2008''