1d0h: Difference between revisions

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THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE

OverviewOverview

The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.

About this StructureAbout this Structure

1D0H is a Single protein structure of sequence from Clostridium tetani. Full crystallographic information is available from OCA.

ReferenceReference

The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:10722735

Page seeded by OCA on Thu Mar 20 10:31:10 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1d0h.gif|left|200px]]<br /><applet load="1d0h" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1d0h.gif|left|200px]]
-caption="1d0h, resolution 2.10&Aring;" />
-'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE'''<br />
+ {{Structure
+|PDB= 1d0h |SIZE=350|CAPTION= <scene name='initialview01'>1d0h</scene>, resolution 2.10&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''THE HC FRAGMENT OF TETANUS TOXIN COMPLEXED WITH N-ACETYL-GALACTOSAMINE'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-D0H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani] with <scene name='pdbligand=A2G:'>A2G</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA].
+D0H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_tetani Clostridium tetani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D0H OCA].
 ==Reference==
-The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10722735 10722735]
+The structures of the H(C) fragment of tetanus toxin with carbohydrate subunit complexes provide insight into ganglioside binding., Emsley P, Fotinou C, Black I, Fairweather NF, Charles IG, Watts C, Hewitt E, Isaacs NW, J Biol Chem. 2000 Mar 24;275(12):8889-94. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10722735 10722735]
 [[Category: Clostridium tetani]]
 [[Category: Single protein]]
@@ Line 27: / Line 36: @@
 [[Category: toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:11:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:31:10 2008''