Rossmann fold: Difference between revisions
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==Extension of the beta sheet by additional strands== | ==Extension of the beta sheet by additional strands== | ||
[[Image:3-phosphoglycerate_dehydrogenase-2P9E-sheet.png|250px|left|thumb| Fig. 4. 3-phosphoglycerate dehydrogenase (2P9E) beta sheet in the NAD binding domain. The two beta-strands that form the core of the Rossmann fold are marked in dark-blue color.]] | [[Image:3-phosphoglycerate_dehydrogenase-2P9E-sheet.png|250px|left|thumb| Fig. 4. 3-phosphoglycerate dehydrogenase (2P9E) beta sheet in the NAD binding domain. The two beta-strands that form the core of the Rossmann fold are marked in dark-blue color.]] | ||
In many (but not all) proteins with βαβ fold, the β-strands may be part of a larger β-sheet with up to | In many (but not all) proteins with βαβ fold, the β-strands may be part of a larger β-sheet with up to seven β-strands. Figure 4 shows five strands forming a β-sheet in phosphoglycerate dehydrogenase (2P9E). Note that the segment connecting the second strand to the third is in coiled confirmation and not helical. Whereas the subsequent connections between strands include α-helix segments. | ||
==Evolutionary origin of the βαβ fold == | ==Evolutionary origin of the βαβ fold == | ||