1cwv: Difference between revisions
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'''CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN''' | {{Structure | ||
|PDB= 1cwv |SIZE=350|CAPTION= <scene name='initialview01'>1cwv</scene>, resolution 2.3Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1CWV is a [ | 1CWV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis Yersinia pseudotuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWV OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of invasin: a bacterial integrin-binding protein., Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ, Science. 1999 Oct 8;286(5438):291-5. PMID:[http:// | Crystal structure of invasin: a bacterial integrin-binding protein., Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ, Science. 1999 Oct 8;286(5438):291-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10514372 10514372] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Yersinia pseudotuberculosis]] | [[Category: Yersinia pseudotuberculosis]] | ||
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[[Category: inv gene]] | [[Category: inv gene]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:29:58 2008'' | ||
Revision as of 11:29, 20 March 2008
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CRYSTAL STRUCTURE OF INVASIN: A BACTERIAL INTEGRIN-BINDING PROTEIN
OverviewOverview
The Yersinia pseudotuberculosis invasin protein promotes bacterial entry by binding to host cell integrins with higher affinity than natural substrates such as fibronectin. The 2.3 angstrom crystal structure of the invasin extracellular region reveals five domains that form a 180 angstrom rod with structural similarities to tandem fibronectin type III domains. The integrin-binding surfaces of invasin and fibronectin include similarly located key residues, but in the context of different folds and surface shapes. The structures of invasin and fibronectin provide an example of convergent evolution, in which invasin presents an optimized surface for integrin binding, in comparison with host substrates.
About this StructureAbout this Structure
1CWV is a Single protein structure of sequence from Yersinia pseudotuberculosis. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of invasin: a bacterial integrin-binding protein., Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ, Science. 1999 Oct 8;286(5438):291-5. PMID:10514372
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