4uo2: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of the A_Equine_Richmond_07 H3 haemagglutinin in complex with Sialyl Lewis X==
+<StructureSection load='4uo2' size='340' side='right' caption='[[4uo2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4uo2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UO2 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene><br>
+<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
+<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4unw|4unw]], [[4unx|4unx]], [[4uny|4uny]], [[4unz|4unz]], [[4uo0|4uo0]], [[4uo1|4uo1]], [[4uo3|4uo3]], [[4uo4|4uo4]], [[4uo5|4uo5]], [[4uo6|4uo6]], [[4uo7|4uo7]], [[4uo8|4uo8]], [[4uo9|4uo9]], [[4uoa|4uoa]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uo2 RCSB], [http://www.ebi.ac.uk/pdbsum/4uo2 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In 2004 an hemagglutinin 3 neuraminidase 8 (H3N8) equine influenza virus was transmitted from horses to dogs in Florida and subsequently spread throughout the United States and to Europe. To understand the molecular basis of changes in the antigenicity of H3 hemagglutinins (HAs) that have occurred during virus evolution in horses, and to investigate the role of HA in the equine to canine cross-species transfer, we used X-ray crystallography to determine the structures of the HAs from two antigenically distinct equine viruses and from a canine virus. Structurally all three are very similar with the majority of amino acid sequence differences between the two equine HAs located on the virus membrane-distal molecular surface. HAs of canine viruses are distinct in containing a Trp-222--&gt;Leu substitution in the receptor binding site that influences specificity for receptor analogs. In the fusion subdomain of canine and recent equine virus HAs a unique difference is observed by comparison with all other HAs examined to date. Analyses of site-specific mutant HAs indicate that a single amino acid substitution, Thr-30--&gt;Ser, influences interactions between N-terminal and C-terminal regions of the subdomain that are important in the structural changes required for membrane fusion activity. Both structural modifications may have facilitated the transmission of H3N8 influenza from horses to dogs.
-The entry 4uo2 is ON HOLD  until Paper Publication
+Recent evolution of equine influenza and the origin of canine influenza.,Collins PJ, Vachieri SG, Haire LF, Ogrodowicz RW, Martin SR, Walker PA, Xiong X, Gamblin SJ, Skehel JJ Proc Natl Acad Sci U S A. 2014 Jul 14. pii: 201406606. PMID:25024224<ref>PMID:25024224</ref>
-Authors: Vachieri, S.G., Collins, P.J., Haire, L.F., Ogrodowicz, R.W., Martin, S.R., Walker, P.A., Xiong, X., Gamblin, S.J., Skehel, J.J.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: Structure of the A_Equine_Richmond_07 H3 haemagglutinin in complex with Sialyl Lewis X
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Collins, P J.]]
+[[Category: Gamblin, S J.]]
+[[Category: Haire, L F.]]
+[[Category: Martin, S R.]]
+[[Category: Ogrodowicz, R W.]]
+[[Category: Skehel, J J.]]
+[[Category: Vachieri, S G.]]
+[[Category: Walker, P A.]]
+[[Category: Xiong, X.]]
+[[Category: Canine]]
+[[Category: Equine]]
+[[Category: Viral protein]]