Keratins: Difference between revisions
m Updated figure numbers |
mNo edit summary |
||
| Line 1: | Line 1: | ||
Note: This entry on keratins has been featured in Biochem. Mol. Biol. Educ. <ref name="Hanukoglu-2013">PMID:24265184</ref>. | Note: This entry on keratins has been featured in Biochem. Mol. Biol. Educ. <ref name="Hanukoglu-2013">PMID:24265184</ref>. | ||
Keratin is the name given to a large family of homologous proteins that have a filamentous (fibrous) structure. These proteins are expressed in epithelial cells and in epidermal cells where | Keratin is the name given to a large family of homologous proteins that have a filamentous (fibrous) structure. These proteins are expressed in epithelial cells and in epidermal cells where they are assembled forming cytoskeletal structures within the cell and epidermal derivatives such as hair, nail and horn <ref>PMID:18461349</ref>. | ||
The keratins represent the largest branch within the super-family of intermediate-filament (IF) proteins <ref name="Godsel-2008">PMID:18083519</ref> <ref>PMID:19587451</ref>. Keratins are grouped into two families termed as type I and type II keratins based on their sequence homology <ref name="Hanukoglu-1983">PMID:6191871</ref>. Similarly, other IF proteins are also grouped into families termed consecutively as types III, IV, V and VI IF proteins, based on their sequence homology <ref>PMID:8982454</ref>. These families include desmin, vimentin, neurofilament protein and GFAP that are expressed in specific tissues and cell types <ref name="Godsel-2008" />. The IF family of lamins are located on the nuclear lamina and are ubiquitously expressed <ref name="Godsel-2008" />. | The keratins represent the largest branch within the super-family of intermediate-filament (IF) proteins <ref name="Godsel-2008">PMID:18083519</ref> <ref>PMID:19587451</ref>. Keratins are grouped into two families termed as type I and type II keratins based on their sequence homology <ref name="Hanukoglu-1983">PMID:6191871</ref>. Similarly, other IF proteins are also grouped into families termed consecutively as types III, IV, V and VI IF proteins, based on their sequence homology <ref>PMID:8982454</ref>. These families include desmin, vimentin, neurofilament protein and GFAP that are expressed in specific tissues and cell types <ref name="Godsel-2008" />. The IF family of lamins are located on the nuclear lamina and are ubiquitously expressed <ref name="Godsel-2008" />. | ||