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HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL

OverviewOverview

The cell cycle regulatory protein CksHs2 binds to the catalytic subunit of the cyclin-dependent kinases (Cdk's) and is essential for their biological function. The crystal structure of the protein was determined at 2.1 A resolution. The CksHs2 structure is an unexpected hexamer formed by the symmetric assembly of three interlocked dimers into an unusual 12-stranded beta barrel fold that may represent a prototype for this class of protein structures. Sequence-conserved regions form the unusual beta strand exchange between the subunits of the dimer, and the metal and anion binding sites associated with the hexamer assembly. The two other sequence-conserved regions line a 12 A diameter tunnel through the beta barrel and form the six exposed, charged helix pairs. Six kinase subunits can be modeled to bind the assembled hexamer without collision, and therefore this CksHs2 hexamer may participate in cell cycle control by acting as the hub for Cdk multimerization in vivo.

About this StructureAbout this Structure

1CKS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control., Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA, Science. 1993 Oct 15;262(5132):387-95. PMID:8211159

Page seeded by OCA on Thu Mar 20 10:25:37 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1cks.jpg|left|200px]]<br /><applet load="1cks" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1cks.jpg|left|200px]]
-caption="1cks, resolution 2.1&Aring;" />
-'''HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL'''<br />
+ {{Structure
+|PDB= 1cks |SIZE=350|CAPTION= <scene name='initialview01'>1cks</scene>, resolution 2.1&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''HUMAN CKSHS2 ATOMIC STRUCTURE: A ROLE FOR ITS HEXAMERIC ASSEMBLY IN CELL CYCLE CONTROL'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-CKS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKS OCA].
+CKS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CKS OCA].
 ==Reference==
-Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control., Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA, Science. 1993 Oct 15;262(5132):387-95. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8211159 8211159]
+Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control., Parge HE, Arvai AS, Murtari DJ, Reed SI, Tainer JA, Science. 1993 Oct 15;262(5132):387-95. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8211159 8211159]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
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 [[Category: cell division]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:07:06 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:25:37 2008''