1bx2: Difference between revisions

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CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN

OverviewOverview

Susceptibility to multiple sclerosis is associated with the human histocompatibility leukocyte antigen (HLA)-DR2 (DRB1*1501) haplotype. The structure of HLA-DR2 was determined with a bound peptide from human myelin basic protein (MBP) that is immunodominant for human MBP-specific T cells. Residues of MBP peptide that are important for T cell receptor recognition are prominent, solvent exposed residues in the crystal structure. A distinguishing feature of the HLA-DR2 peptide binding site is a large, primarily hydrophobic P4 pocket that accommodates a phenylalanine of the MBP peptide. The necessary space for this aromatic side chain is created by an alanine at the polymorphic DRbeta 71 position. These features make the P4 pocket of HLA-DR2 distinct from DR molecules associated with other autoimmune diseases.

About this StructureAbout this Structure

1BX2 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein., Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW, J Exp Med. 1998 Oct 19;188(8):1511-20. PMID:9782128

Page seeded by OCA on Thu Mar 20 10:16:55 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1bx2.gif|left|200px]]<br /><applet load="1bx2" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1bx2.gif|left|200px]]
-caption="1bx2, resolution 2.6&Aring;" />
-'''CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN'''<br />
+ {{Structure
+|PDB= 1bx2 |SIZE=350|CAPTION= <scene name='initialview01'>1bx2</scene>, resolution 2.6&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''CRYSTAL STRUCTURE OF HLA-DR2 (DRA*0101,DRB1*1501) COMPLEXED WITH A PEPTIDE FROM HUMAN MYELIN BASIC PROTEIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-BX2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BX2 OCA].
+BX2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BX2 OCA].
 ==Reference==
-Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein., Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW, J Exp Med. 1998 Oct 19;188(8):1511-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9782128 9782128]
+Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein., Smith KJ, Pyrdol J, Gauthier L, Wiley DC, Wucherpfennig KW, J Exp Med. 1998 Oct 19;188(8):1511-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9782128 9782128]
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
@@ Line 24: / Line 33: @@
 [[Category: myelin basic protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:00:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:16:55 2008''