1br0: Difference between revisions
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[[Image:1br0.gif|left|200px]] | [[Image:1br0.gif|left|200px]] | ||
'''THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A''' | {{Structure | ||
|PDB= 1br0 |SIZE=350|CAPTION= <scene name='initialview01'>1br0</scene> | |||
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'''THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BR0 is a [ | 1BR0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BR0 OCA]. | ||
==Reference== | ==Reference== | ||
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A., Fernandez I, Ubach J, Dulubova I, Zhang X, Sudhof TC, Rizo J, Cell. 1998 Sep 18;94(6):841-9. PMID:[http:// | Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A., Fernandez I, Ubach J, Dulubova I, Zhang X, Sudhof TC, Rizo J, Cell. 1998 Sep 18;94(6):841-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9753330 9753330] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: syntaxin]] | [[Category: syntaxin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:14:35 2008'' | ||
Revision as of 11:14, 20 March 2008
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THREE DIMENSIONAL STRUCTURE OF THE N-TERMINAL DOMAIN OF SYNTAXIN 1A
OverviewOverview
Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membrane syntaxins but not in other syntaxins, indicating a specific role in exocytosis. The domain contains three long alpha helices that form an up-and-down bundle with a left-handed twist. A striking residue conservation is observed throughout a long groove that is likely to provide a specific surface for protein-protein interactions. A highly acidic region binds to the C2A domain of synaptotagmin I in a Ca2+-dependent interaction that may serve as an electrostatic switch in neurotransmitter release.
About this StructureAbout this Structure
1BR0 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A., Fernandez I, Ubach J, Dulubova I, Zhang X, Sudhof TC, Rizo J, Cell. 1998 Sep 18;94(6):841-9. PMID:9753330
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