1bi9: Difference between revisions
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[[Image:1bi9.gif|left|200px]] | [[Image:1bi9.gif|left|200px]] | ||
'''RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND''' | {{Structure | ||
|PDB= 1bi9 |SIZE=350|CAPTION= <scene name='initialview01'>1bi9</scene>, resolution 2.70Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BI9 is a [ | 1BI9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BI9 OCA]. | ||
==Reference== | ==Reference== | ||
The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity., Lamb AL, Newcomer ME, Biochemistry. 1999 May 11;38(19):6003-11. PMID:[http:// | The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity., Lamb AL, Newcomer ME, Biochemistry. 1999 May 11;38(19):6003-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10320326 10320326] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: retinoid]] | [[Category: retinoid]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:11:21 2008'' | ||
Revision as of 11:11, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND
OverviewOverview
Retinoic acid, a hormonally active form of vitamin A, is produced in vivo in a two step process: retinol is oxidized to retinal and retinal is oxidized to retinoic acid. Retinal dehydrogenase type II (RalDH2) catalyzes this last step in the production of retinoic acid in the early embryo, possibly producing this putative morphogen to initiate pattern formation. The enzyme is also found in the adult animal, where it is expressed in the testis, lung, and brain among other tissues. The crystal structure of retinal dehydrogenase type II cocrystallized with nicotinamide adenine dinucleotide (NAD) has been determined at 2.7 A resolution. The structure was solved by molecular replacement using the crystal structure of a mitochondrial aldehyde dehydrogenase (ALDH2) as a model. Unlike what has been described for the structures of two aldehyde dehydrogenases involved in the metabolism of acetaldehyde, the substrate access channel is not a preformed cavity into which acetaldehyde can readily diffuse. Retinal dehydrogenase appears to utilize a disordered loop in the substrate access channel to discriminate between retinaldehyde and short-chain aldehydes.
About this StructureAbout this Structure
1BI9 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity., Lamb AL, Newcomer ME, Biochemistry. 1999 May 11;38(19):6003-11. PMID:10320326
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