1bhd: Difference between revisions

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Revision as of 11:11, 20 March 2008

File:1bhd.gif

, resolution 2.0Å

Gene:

UTRN, DMDL (Homo sapiens)

Coordinates:

save as pdb, mmCIF, xml

SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN

OverviewOverview

Utrophin is a close homologue of dystrophin, the protein defective in Duchenne muscular dystrophy. Like dystrophin, it is composed of three regions: an N-terminal region that binds actin filaments, a large central region with triple coiled-coil repeats, and a C-terminal region that interacts with components in the dystroglycan protein complex at the plasma membrane. The N-terminal actin-binding region consists of two calponin homology domains and is related to the actin-binding domains of a superfamily of proteins including alpha-actinin, spectrin and fimbrin. Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin.

About this StructureAbout this Structure

1BHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin., Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J, J Mol Biol. 1999 Jan 22;285(3):1257-64. PMID:9887274

Page seeded by OCA on Thu Mar 20 10:11:01 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1bhd.gif|left|200px]]<br /><applet load="1bhd" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1bhd.gif|left|200px]]
-caption="1bhd, resolution 2.0&Aring;" />
-'''SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN'''<br />
+ {{Structure
+|PDB= 1bhd |SIZE=350|CAPTION= <scene name='initialview01'>1bhd</scene>, resolution 2.0&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= UTRN, DMDL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-BHD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BHD OCA].
+BHD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BHD OCA].
 ==Reference==
-The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin., Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J, J Mol Biol. 1999 Jan 22;285(3):1257-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9887274 9887274]
+The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin., Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J, J Mol Biol. 1999 Jan 22;285(3):1257-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9887274 9887274]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 20: / Line 29: @@
 [[Category: structural protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:11:01 2008''