1bd2: Difference between revisions
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[[Image:1bd2.gif|left|200px]]< | [[Image:1bd2.gif|left|200px]] | ||
'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201''' | {{Structure | ||
|PDB= 1bd2 |SIZE=350|CAPTION= <scene name='initialview01'>1bd2</scene>, resolution 2.5Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= HLA-A 0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 J BETA 2.7 (BV13S1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V ALPHA 17.2, J ALPHA 54 (ADV21S1A1N2) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3, J BETA 2.7 (BV13S1) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BD2 is a [ | 1BD2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BD2 OCA]. | ||
==Reference== | ==Reference== | ||
Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids., Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC, Immunity. 1998 Apr;8(4):403-11. PMID:[http:// | Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids., Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC, Immunity. 1998 Apr;8(4):403-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9586631 9586631] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human t-lymphotropic virus 1]] | [[Category: Human t-lymphotropic virus 1]] | ||
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[[Category: complex (mhc/viral peptide/receptor)]] | [[Category: complex (mhc/viral peptide/receptor)]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:09:23 2008'' | ||
Revision as of 11:09, 20 March 2008
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| , resolution 2.5Å | |||||||
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| Gene: | HLA-A 0201 (Homo sapiens), V BETA 12.3 J BETA 2.7 (BV13S1) (Homo sapiens), V ALPHA 17.2, J ALPHA 54 (ADV21S1A1N2) (Homo sapiens), V BETA 12.3, J BETA 2.7 (BV13S1) (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
COMPLEX BETWEEN HUMAN T-CELL RECEPTOR B7, VIRAL PEPTIDE (TAX) AND MHC CLASS I MOLECULE HLA-A 0201
OverviewOverview
The three-dimensional structure of a human alphabeta T cell receptor (TCR), B7, bound to the HLA-A2 molecule/HTLV-1 Tax peptide complex was determined by x-ray crystallography. Although different from the A6 TCR, previously studied, in 16 of the 17 residues that contact HLA-A2/Tax, the B7 TCR binds in a similar diagonal manner, only slightly tipped and rotated, relative to the A6 TCR. The structure explains data from functional assays on the specificity differences between the B7 and A6 TCRs for agonist, partial agonist, and null peptides. The existence of a structurally similar diagonal binding mode for TCRs favors mechanisms based on the formation of geometrically defined supramolecular assemblies for initiating signaling.
DiseaseDisease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this StructureAbout this Structure
1BD2 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.
ReferenceReference
Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids., Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC, Immunity. 1998 Apr;8(4):403-11. PMID:9586631
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