1bbd: Difference between revisions
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[[Image:1bbd.gif|left|200px]] | [[Image:1bbd.gif|left|200px]] | ||
'''THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2''' | {{Structure | ||
|PDB= 1bbd |SIZE=350|CAPTION= <scene name='initialview01'>1bbd</scene>, resolution 2.8Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1BBD is a [ | 1BBD is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BBD OCA]. | ||
==Reference== | ==Reference== | ||
Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2., Tormo J, Stadler E, Skern T, Auer H, Kanzler O, Betzel C, Blaas D, Fita I, Protein Sci. 1992 Sep;1(9):1154-61. PMID:[http:// | Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2., Tormo J, Stadler E, Skern T, Auer H, Kanzler O, Betzel C, Blaas D, Fita I, Protein Sci. 1992 Sep;1(9):1154-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1338980 1338980] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Blaas, D.]] | [[Category: Blaas, D.]] | ||
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[[Category: immunoglobulin]] | [[Category: immunoglobulin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:08:46 2008'' | ||
Revision as of 11:08, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
THREE DIMENSIONAL STRUCTURE OF THE FAB FRAGMENT OF A NEUTRALIZING ANTIBODY TO HUMAN RHINOVIRUS SEROTYPE 2
OverviewOverview
The crystal structure of the antigen-binding fragment of a monoclonal antibody (8F5) that neutralizes human rhinovirus serotype 2 has been determined by X-ray diffraction studies. Antibody 8F5, obtained by immunization with native HRV2 virions, cross-reacts with peptides of the viral capsid protein VP2, which contribute to the neutralizing immunogenic site B in this serotype. The structure was solved by the molecular replacement method and has been refined to an R-factor of 18.9% at 2.8 A resolution. The elbow angle, relating the variable and constant modules of the molecule is 127 degrees, representing the smallest elbow angle observed so far in an Fab fragment. Furthermore, the charged residues of the epitope can be well accommodated in the antigen-binding site. This is the first crystal structure reported for an antibody directed against an icosahedral virus.
About this StructureAbout this Structure
1BBD is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of the Fab fragment of a neutralizing antibody to human rhinovirus serotype 2., Tormo J, Stadler E, Skern T, Auer H, Kanzler O, Betzel C, Blaas D, Fita I, Protein Sci. 1992 Sep;1(9):1154-61. PMID:1338980
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