1bar: Difference between revisions

Revision as of 11:08, 20 March 2008

, resolution 2.7Å

Coordinates:

THREE-DIMENSIONAL STRUCTURES OF ACIDIC AND BASIC FIBROBLAST GROWTH FACTORS

OverviewOverview

Members of the fibroblast growth factor (FGF) family of proteins stimulate the proliferation and differentiation of a variety of cell types through receptor-mediated pathways. The three-dimensional structures of two members of this family, bovine acidic FGF and human basic FGF, have been crystallographically determined. These structures contain 12 antiparallel beta strands organized into a folding pattern with approximate threefold internal symmetry. Topologically equivalent folds have been previously observed for soybean trypsin inhibitor and interleukins-1 beta and -1 alpha. The locations of sequences implicated in receptor and heparin binding by FGF are presented. These sites include beta-sheet strand 10, which is adjacent to the site of an extended sequence insertion in several oncogene proteins of the FGF family, and which shows sequence conservation among the FGF family and interleukin-1 beta.

About this StructureAbout this Structure

1BAR is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

ReferenceReference

Three-dimensional structures of acidic and basic fibroblast growth factors., Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC, Science. 1991 Jan 4;251(4989):90-3. PMID:1702556

Page seeded by OCA on Thu Mar 20 10:08:30 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:1bar.jpg|left|200px]]<br /><applet load="1bar" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1bar.jpg|left|200px]]
-caption="1bar, resolution 2.7&Aring;" />
-'''THREE-DIMENSIONAL STRUCTURES OF ACIDIC AND BASIC FIBROBLAST GROWTH FACTORS'''<br />
+ {{Structure
+|PDB= 1bar |SIZE=350|CAPTION= <scene name='initialview01'>1bar</scene>, resolution 2.7&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE=
+}}
+'''THREE-DIMENSIONAL STRUCTURES OF ACIDIC AND BASIC FIBROBLAST GROWTH FACTORS'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-BAR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAR OCA].
+BAR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAR OCA].
 ==Reference==
-Three-dimensional structures of acidic and basic fibroblast growth factors., Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC, Science. 1991 Jan 4;251(4989):90-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1702556 1702556]
+Three-dimensional structures of acidic and basic fibroblast growth factors., Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC, Science. 1991 Jan 4;251(4989):90-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1702556 1702556]
 [[Category: Bos taurus]]
 [[Category: Single protein]]
@@ Line 23: / Line 32: @@
 [[Category: growth factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:53:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:08:30 2008''