1awc: Difference between revisions

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Revision as of 11:03, 20 March 2008

File:1awc.gif

, resolution 2.150Å

Gene:

GABP ALPHA (Mus musculus), GABP BETA 1 (Mus musculus)

Coordinates:

save as pdb, mmCIF, xml

MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA

OverviewOverview

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.

About this StructureAbout this Structure

1AWC is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:9461436

Page seeded by OCA on Thu Mar 20 10:03:04 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1awc.gif|left|200px]]<br /><applet load="1awc" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1awc.gif|left|200px]]
-caption="1awc, resolution 2.150&Aring;" />
-'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''<br />
+ {{Structure
+|PDB= 1awc |SIZE=350|CAPTION= <scene name='initialview01'>1awc</scene>, resolution 2.150&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= GABP ALPHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), GABP BETA 1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+}}
+'''MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-AWC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA].
+AWC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AWC OCA].
 ==Reference==
-The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9461436 9461436]
+The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA., Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C, Science. 1998 Feb 13;279(5353):1037-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9461436 9461436]
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
 [[Category: Batchelor, A H.]]
 [[Category: Wolberger, C.]]
-[[Category: ankyrin repeats]]
+[[Category: ankyrin repeat]]
 [[Category: complex (transcription regulation/dna)]]
 [[Category: dna-binding]]
@@ Line 22: / Line 31: @@
 [[Category: transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:55 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:03:04 2008''