3rin: Difference between revisions

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-[[Image:3rin.jpg|left|200px]]
+==p38 kinase crystal structure in complex with small molecule inhibitor==
+<StructureSection load='3rin' size='340' side='right' caption='[[3rin]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3rin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RIN FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=I2O:N-CYCLOPROPYL-4-METHYL-3-(2-OXO-1,2-DIHYDROSPIRO[CYCLOPENTANE-1,3-INDOL]-6-YL)BENZAMIDE'>I2O</scene><br>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rin RCSB], [http://www.ebi.ac.uk/pdbsum/3rin PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The use of structure-based design and molecular modeling led to the discovery of indolin-2-one derivatives as potent and selective p38alpha inhibitors. The predicted binding mode was confirmed by X-ray crystallography.
-<!--
+Indolin-2-one p38alpha inhibitors I: design, profiling and crystallographic binding mode.,Eastwood P, Gonzalez J, Gomez E, Vidal B, Caturla F, Roca R, Balague C, Orellana A, Dominguez M Bioorg Med Chem Lett. 2011 Jul 15;21(14):4130-3. Epub 2011 Jun 6. PMID:21696951<ref>PMID:21696951</ref>
-The line below this paragraph, containing "STRUCTURE_3rin", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_3rin|  PDB=3rin  |  SCENE=  }}
-===p38 kinase crystal structure in complex with small molecule inhibitor===
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+</div>
+==See Also==
-<!--
+*[[Mitogen-activated protein kinase|Mitogen-activated protein kinase]]
-The line below this paragraph, {{ABSTRACT_PUBMED_21696951}}, adds the Publication Abstract to the page
+== References ==
-(as it appears on PubMed at http://www.pubmed.gov), where 21696951 is the PubMed ID number.
+<references/>
--->
+__TOC__
-{{ABSTRACT_PUBMED_21696951}}
+</StructureSection>
-==About this Structure==
-[[3rin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIN OCA].
-==Reference==
-<ref group="xtra">PMID:021696951</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
 [[Category: Mitogen-activated protein kinase]]