1afv: Difference between revisions
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[[Image:1afv.gif|left|200px]] | [[Image:1afv.gif|left|200px]] | ||
'''HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3''' | {{Structure | ||
|PDB= 1afv |SIZE=350|CAPTION= <scene name='initialview01'>1afv</scene>, resolution 3.7Å | |||
|SITE= <scene name='pdbsite=CP1:Cyclophilin+Binding+Site'>CP1</scene> and <scene name='pdbsite=CP2:Cyclophilin+Binding+Site'>CP2</scene> | |||
|LIGAND= <scene name='pdbligand=PB:LEAD (II) ION'>PB</scene> | |||
|ACTIVITY= | |||
|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1]) | |||
}} | |||
'''HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1AFV is a [ | 1AFV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AFV OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of dimeric HIV-1 capsid protein., Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG, Nat Struct Biol. 1996 Sep;3(9):763-70. PMID:[http:// | Crystal structure of dimeric HIV-1 capsid protein., Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG, Nat Struct Biol. 1996 Sep;3(9):763-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8784350 8784350] | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: p24]] | [[Category: p24]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:57:00 2008'' | ||
Revision as of 10:57, 20 March 2008
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| , resolution 3.7Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | and | ||||||
| Ligands: | |||||||
| Gene: | GAG (Human immunodeficiency virus 1) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3
OverviewOverview
X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven alpha-helices, five of which are arranged in a coiled coil-like structure. Sequence assignments were made for two of the helices, and tentative connectivity of the remainder of the protein was confirmed by the recent solution structure of a monomeric N-terminal fragment. The C-terminal third of the protein is mostly disordered in the crystal. The longest helices in the coiled coil-like structure are separated by a long, highly antigenic peptide that includes the binding site of an antibody fragment complexed with CA in the crystal. The site of binding of the Fab, the position of the antigenic loop and the site of cleavage between the matrix protein and CA establish the side of the dimer that would be on the exterior of the retroviral core.
About this StructureAbout this Structure
1AFV is a Protein complex structure of sequences from Human immunodeficiency virus 1 and Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of dimeric HIV-1 capsid protein., Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG, Nat Struct Biol. 1996 Sep;3(9):763-70. PMID:8784350
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