1ab8: Difference between revisions
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[[Image:1ab8.gif|left|200px]] | [[Image:1ab8.gif|left|200px]] | ||
'''RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX''' | {{Structure | ||
|PDB= 1ab8 |SIZE=350|CAPTION= <scene name='initialview01'>1ab8</scene>, resolution 2.2Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=FOK:FORSKOLIN'>FOK</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Adenylate_cyclase Adenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.1 4.6.1.1] | |||
|GENE= PPROEX-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | |||
}} | |||
'''RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1AB8 is a [ | 1AB8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AB8 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the adenylyl cyclase catalytic core., Zhang G, Liu Y, Ruoho AE, Hurley JH, Nature. 1997 Mar 20;386(6622):247-53. PMID:[http:// | Structure of the adenylyl cyclase catalytic core., Zhang G, Liu Y, Ruoho AE, Hurley JH, Nature. 1997 Mar 20;386(6622):247-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9069282 9069282] | ||
[[Category: Adenylate cyclase]] | [[Category: Adenylate cyclase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
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[[Category: plasmid]] | [[Category: plasmid]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:55:22 2008'' | ||
Revision as of 10:55, 20 March 2008
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| , resolution 2.2Å | |||||||
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| Ligands: | |||||||
| Gene: | PPROEX-1 (Rattus norvegicus) | ||||||
| Activity: | Adenylate cyclase, with EC number 4.6.1.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX
OverviewOverview
Mammalian adenylyl cyclases contain two conserved regions, C1 and C2, which are responsible for forskolin- and G-protein-stimulated catalysis. The structure of the C2 catalytic region of type II rat adenylyl cyclase has an alpha/beta class fold in a wreath-like dimer, which has a central cleft. Two forskolin molecules bind in hydrophobic pockets at the ends of cleft. The central part of the cleft is lined by charged residues implicated in ATP binding. Forskolin appears to activate adenylyl cyclase by promoting the assembly of the active dimer and by direct interaction within the catalytic cleft. Other adenylyl cyclase regulators act at the dimer interface or on a flexible C-terminal region.
About this StructureAbout this Structure
1AB8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the adenylyl cyclase catalytic core., Zhang G, Liu Y, Ruoho AE, Hurley JH, Nature. 1997 Mar 20;386(6622):247-53. PMID:9069282
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