4ckp: Difference between revisions

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-{{STRUCTURE_4ckp|  PDB=4ckp  |  SCENE=  }}
+==Structure of an N-terminal fragment of Leishmania SAS-6 that contains part of its coiled coil domain==
-===Structure of an N-terminal fragment of Leishmania SAS-6 that contains part of its coiled coil domain===
+<StructureSection load='4ckp' size='340' side='right' caption='[[4ckp]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
-{{ABSTRACT_PUBMED_24596152}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ckp]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CKP FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ckm|4ckm]], [[4ckn|4ckn]]</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ckp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ckp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ckp RCSB], [http://www.ebi.ac.uk/pdbsum/4ckp PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Centrioles are cylindrical cell organelles with a ninefold symmetric peripheral microtubule array that is essential to template cilia and flagella. They are built around a central cartwheel assembly that is organized through homo-oligomerization of the centriolar protein SAS-6, but whether SAS-6 self-assembly can dictate cartwheel and thereby centriole symmetry is unclear. Here we show that Leishmania major SAS-6 crystallizes as a 9-fold symmetric cartwheel and provide the X-ray structure of this assembly at a resolution of 3.5 A. We furthermore demonstrate that oligomerization of Leishmania SAS-6 can be inhibited by a small molecule in vitro and provide indications for its binding site. Our results firmly establish that SAS-6 can impose cartwheel symmetry on its own and indicate how this process might occur mechanistically in vivo. Importantly, our data also provide a proof-of-principle that inhibition of SAS-6 oligomerization by small molecules is feasible. DOI: http://dx.doi.org/10.7554/eLife.01812.001.
-==About this Structure==
+Structure of the SAS-6 cartwheel hub from Leishmania major.,van Breugel M, Wilcken R, McLaughlin SH, Rutherford TJ, Johnson CM Elife. 2014 Jan 1;3:e01812. doi: 10.7554/eLife.01812. PMID:24596152<ref>PMID:24596152</ref>
-[[4ckp]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CKP OCA].
-==Reference==
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024596152</ref><references group="xtra"/><references/>
+</div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Leima]]
 [[Category: Breugel, M van.]]
 [[Category: Basal body]]