4py0: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
[[4py0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY0 OCA]. <br> | [[4py0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY0 OCA]. <br> | ||
<b>Related:</b> [[4ntj|4ntj]], [[4pxz|4pxz]]<br> | <b>[[Ligand|Ligands:]]</b> <scene name='pdbligand=6AT:2-(METHYLSULFANYL)ADENOSINE+5-(TETRAHYDROGEN+TRIPHOSPHATE)'>6AT</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene><br> | ||
<b>[[Related_structure|Related:]]</b> [[4ntj|4ntj]], [[4pxz|4pxz]]<br> | |||
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | ||
<b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4py0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4py0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4py0 RCSB], [http://www.ebi.ac.uk/pdbsum/4py0 PDBsum]</span><br> | |||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry. | ||
Revision as of 13:07, 30 April 2014
Crystal structure of P2Y12 receptor in complex with 2MeSATPCrystal structure of P2Y12 receptor in complex with 2MeSATP
Structural highlights4py0 is a 1 chain structure. Full crystallographic information is available from OCA. Ligands: , Disease[P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry. Function[P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation. References |
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Cherezov, V.
- GPCR, GPCR Network.
- Gao, Z G.
- Han, G W.
- Jacobson, K A.
- Jiang, H.
- Katritch, V.
- Li, T.
- Ma, L.
- Muller, C E.
- Paoletta, S.
- Stevens, R C.
- Wu, B.
- Yang, H.
- Zhang, D.
- Zhang, J.
- Zhang, K.
- Zhang, W.
- Zhao, Q.
- Gpcr
- Gpcr network
- Membrane
- Membrane protein
- Partial agonist-bound
- Platelet activation
- Psi-biology
- Purinergic receptor p2y12
- Signaling membrane protein
- Signaling protein-nucleotide complex
- Structural genomic