2bz0: Difference between revisions
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[[Category: riboflavin biosynthesis]] | [[Category: riboflavin biosynthesis]] | ||
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CRYSTAL STRUCTURE OF E. COLI GTP CYCLOHYDROLASE II IN COMPLEX WITH GTP ANALOGUE, GMPCPP, AND ZINC
OverviewOverview
GTP cyclohydrolase II converts GTP to, 2,5-diamino-6-beta-ribosyl-4(3H)-pyrimidinone 5'-phosphate, formate and, pyrophosphate, the first step in riboflavin biosynthesis. The essential, role of riboflavin in metabolism and the absence of GTP cyclohydrolase II, in higher eukaryotes makes it a potential novel selective antimicrobial, drug target. GTP cyclohydrolase II catalyzes a distinctive overall, reaction from GTP cyclohydrolase I; the latter converts GTP to, dihydroneopterin triphosphate, utilized in folate and tetrahydrobiopterin, biosynthesis. The structure of GTP cyclohydrolase II determined at 1.54-A, resolution reveals both a different protein fold to GTP cyclohydrolase I, and distinctive molecular recognition determinants for GTP; although in, both enzymes there is a bound ... [(full description)]
About this StructureAbout this Structure
2BZ0 is a [Single protein] structure of sequence from [Escherichia coli] with ZN, MG and G2P as [ligands]. Active as [GTP cyclohydrolase II], with EC number [3.5.4.25]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
GTP cyclohydrolase II structure and mechanism., Ren J, Kotaka M, Lockyer M, Lamb HK, Hawkins AR, Stammers DK, J Biol Chem. 2005 Nov 4;280(44):36912-9. Epub 2005 Aug 22. PMID:16115872
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