Sandbox Reserved 191: Difference between revisions
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=Introduction= | =Introduction= | ||
'''<scene name='43/436866/Overall-3-rainbow/1'>Palmitoyl-protein thioesterase 1 (PPT-1)</scene>''' is a small glycoprotein [[hydrolase]] found in the lysosome that breaks the thioester bond between cysteine [[amino acids]] and <scene name='43/436866/Palmitic_acid_self/1'>palmitic acid</scene><ref name="newest">PMID:24083319</ref>. PPT-1 is a homodimer that is composed primarily of alpha helices and beta sheets with a hydrophobic groove that allows the palmitic acid[http://en.wikipedia.org/wiki/Palmitic_acid] to bind, exposing the thioester bond to the catalytic triad. PPT-1 was first found as an enzyme that removed palmitate from [[GTPase HRas]], in addition to many other cellular substrates <ref name="mutations">PMID:10781062</ref>. When PPT-1 is not functioning properly, lipid modified proteins can build up in the cells, causing lysosomal storage diseases and aiding in tumor formation <ref name="INCL">PMID:19302939</ref> | '''<scene name='43/436866/Overall-3-rainbow/1'>Palmitoyl-protein thioesterase 1 (PPT-1)</scene>''' is a small glycoprotein [[hydrolase]] found in the lysosome that breaks the thioester bond between cysteine [[amino acids]] and <scene name='43/436866/Palmitic_acid_self/1'>palmitic acid</scene><ref name="newest">PMID:24083319</ref>. PPT-1 is a homodimer that is composed primarily of alpha helices and beta sheets with a hydrophobic groove that allows the [[palmitic acid]][http://en.wikipedia.org/wiki/Palmitic_acid] to bind, exposing the thioester bond to the catalytic triad. PPT-1 was first found as an enzyme that removed palmitate from [[GTPase HRas]], in addition to many other cellular substrates <ref name="mutations">PMID:10781062</ref>. When PPT-1 is not functioning properly, lipid modified proteins can build up in the cells, causing lysosomal storage diseases and aiding in tumor formation <ref name="INCL">PMID:19302939</ref> | ||
[[Image:Protopedia_surface_w_acid.png |300px|left|thumb|Figure 1: Surface view of PPT-1 (green) showing the hydrophobic groove and palmitate (blue with red oxygen)]] | [[Image:Protopedia_surface_w_acid.png |300px|left|thumb|Figure 1: Surface view of PPT-1 (green) showing the hydrophobic groove and palmitate (blue with red oxygen)]] | ||