2bf7: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
m Protected "2bf7" [edit=sysop:move=sysop]
No edit summary
Line 1: Line 1:
[[Image:2bf7.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_2bf7", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_2bf7|  PDB=2bf7  |  SCENE=  }}  
{{STRUCTURE_2bf7|  PDB=2bf7  |  SCENE=  }}  
===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND BIOPTERIN===
===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND BIOPTERIN===
{{ABSTRACT_PUBMED_16055151}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/PTR1_LEIMA PTR1_LEIMA]] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).<ref>PMID:7972081</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_16055151}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16055151 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16055151}}


==About this Structure==
==About this Structure==
[[2bf7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BF7 OCA].  
[[2bf7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BF7 OCA].  
==See Also==
*[[Pteridine reductase|Pteridine reductase]]


==Reference==
==Reference==
<ref group="xtra">PMID:016055151</ref><references group="xtra"/>
<ref group="xtra">PMID:016055151</ref><references group="xtra"/><references/>
[[Category: Leishmania major]]
[[Category: Leishmania major]]
[[Category: Pteridine reductase]]
[[Category: Pteridine reductase]]

Revision as of 11:35, 23 April 2014

Template:STRUCTURE 2bf7

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND BIOPTERINLEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND BIOPTERIN

Template:ABSTRACT PUBMED 16055151

FunctionFunction

[PTR1_LEIMA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).[1]

About this StructureAbout this Structure

2bf7 is a 4 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Schuttelkopf AW, Hardy LW, Beverley SM, Hunter WN. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. J Mol Biol. 2005 Sep 9;352(1):105-16. PMID:16055151 doi:http://dx.doi.org/10.1016/j.jmb.2005.06.076
  1. ↑ Bello AR, Nare B, Freedman D, Hardy L, Beverley SM. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11442-6. PMID:7972081

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2bf7&oldid=1917625"