2bfp: Difference between revisions

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[[Image:2bfp.png|left|200px]]
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{{STRUCTURE_2bfp|  PDB=2bfp  |  SCENE=  }}  
{{STRUCTURE_2bfp|  PDB=2bfp  |  SCENE=  }}  
===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND TETRAHYDROBIOPTERIN===
===LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND TETRAHYDROBIOPTERIN===
{{ABSTRACT_PUBMED_16055151}}


 
==Function==
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[[http://www.uniprot.org/uniprot/PTR1_LEIMA PTR1_LEIMA]] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).<ref>PMID:7972081</ref>
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{{ABSTRACT_PUBMED_16055151}}


==About this Structure==
==About this Structure==
[[2bfp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFP OCA].  
[[2bfp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BFP OCA].  
==See Also==
*[[Pteridine reductase|Pteridine reductase]]


==Reference==
==Reference==
<ref group="xtra">PMID:016055151</ref><references group="xtra"/>
<ref group="xtra">PMID:016055151</ref><references group="xtra"/><references/>
[[Category: Leishmania major]]
[[Category: Leishmania major]]
[[Category: Pteridine reductase]]
[[Category: Pteridine reductase]]

Revision as of 11:19, 23 April 2014

Template:STRUCTURE 2bfp

LEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND TETRAHYDROBIOPTERINLEISHMANIA MAJOR PTERIDINE REDUCTASE 1 IN COMPLEX WITH NADP AND TETRAHYDROBIOPTERIN

Template:ABSTRACT PUBMED 16055151

FunctionFunction

[PTR1_LEIMA] Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).[1]

About this StructureAbout this Structure

2bfp is a 4 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1]

  1. ↑ Schuttelkopf AW, Hardy LW, Beverley SM, Hunter WN. Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design. J Mol Biol. 2005 Sep 9;352(1):105-16. PMID:16055151 doi:http://dx.doi.org/10.1016/j.jmb.2005.06.076
  1. ↑ Bello AR, Nare B, Freedman D, Hardy L, Beverley SM. PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11442-6. PMID:7972081

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