Sandbox Reserved 918: Difference between revisions
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<StructureSection load='1X70' size='350' frame='true' align='right' caption='Biological Dimer of DPP IV' scene='57/573132/1x70_basic_dimer/1'> | <StructureSection load='1X70' size='350' frame='true' align='right' caption='Biological Dimer of DPP IV' scene='57/573132/1x70_basic_dimer/1'> | ||
===Binding Pocket=== | ===Binding Pocket=== | ||
The specificity of the DPP IV for proline from other amino acids can be seen in the <scene name='57/573132/1x70_basic_dimer_bindingpocket/1'>binding pocket</scene> <scene name='57/573132/1x70_basic_dimer_bindingzoomed/2'>(zoomed binding pocket)</scene> where two glutamates, <scene name='57/573132/1x70_glutamates/ | The specificity of the DPP IV for proline from other amino acids can be seen in the <scene name='57/573132/1x70_basic_dimer_bindingpocket/1'>binding pocket</scene> <scene name='57/573132/1x70_basic_dimer_bindingzoomed/2'>(zoomed binding pocket)</scene> where two glutamates, <scene name='57/573132/1x70_glutamates/5'>Glu205-Glu206</scene> orient the substrate allowing only small residues like proline or alanine to fit. The [http://en.wikipedia.org/wiki/Glutamic_acid glutamates] form a [http://en.wikipedia.org/wiki/Salt_bridge_(protein_and_supramolecular) salt bridge] with the N-terminus, positioning the substrate so that only two amino acids can fit into position for hydrolysis. <ref name="Gorrell">PMID: 15584901</ref> Examples of DPP IV substrates with alanine or proline at their N-terminus are: | ||
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