4l1x: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4l1x|  PDB=4l1x  |  SCENE=  }}
+===Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone===
+{{ABSTRACT_PUBMED_24434280}}
-The entry 4l1x is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Defects in AKR1C2 are a cause of 46,XY sex reversal type 8 (SRXY8) [MIM:[http://omim.org/entry/614279 614279]]. A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.<ref>PMID:21802064</ref>
-Authors: Zhang, B., Hu, X.-J., Lin, S.-X.
+==Function==
+[[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.<ref>PMID:8573067</ref>
-Description: Crystal Structuer of Human 3-alpha Hydroxysteroid Dehydrogenase Type 3 V54L Mutant in Complex with NADP+ and Progesterone
+==About this Structure==
+[[4l1x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1X OCA].
+==Reference==
+<ref group="xtra">PMID:024434280</ref><references group="xtra"/><references/>
+[[Category: Hu, X J.]]
+[[Category: Lin, S X.]]
+[[Category: Zhang, B.]]
+[[Category: Akr]]
+[[Category: Akr1c2]]
+[[Category: Aldo-keto reductase]]
+[[Category: Alpha-beta barrel]]
+[[Category: Human 3-alpha hsd3]]
+[[Category: Nadph]]
+[[Category: Oxidoreductase]]