4np2: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4np2| PDB=4np2 | SCENE= }} | |||
===Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule=== | |||
{{ABSTRACT_PUBMED_24606063}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD44_MOUSE CD44_MOUSE]] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing. | |||
==About this Structure== | |||
[[4np2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NP2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024606063</ref><references group="xtra"/><references/> | |||
[[Category: Finzel, B.]] | |||
[[Category: Liu, L K.]] | |||
[[Category: Cell adhesion-inhibitor complex]] | |||
[[Category: Cell surface]] | |||
[[Category: Cell surface receptor]] | |||
[[Category: Hyaluronan]] | |||
[[Category: Link module]] | |||
[[Category: Non-glycosylated]] | |||
Revision as of 12:39, 16 April 2014
Crystal structure of the murine CD44 hyaluronan binding domain complex with a small moleculeCrystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule
Template:ABSTRACT PUBMED 24606063
FunctionFunction
[CD44_MOUSE] Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.
About this StructureAbout this Structure
4np2 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Liu LK, Finzel BC. Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein-Carbohydrate Interaction Inhibitors. J Med Chem. 2014 Mar 27;57(6):2714-25. doi: 10.1021/jm5000276. Epub 2014 Mar 7. PMID:24606063 doi:http://dx.doi.org/10.1021/jm5000276