2ypu: Difference between revisions
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{{STRUCTURE_2ypu| PDB=2ypu | SCENE= }} | {{STRUCTURE_2ypu| PDB=2ypu | SCENE= }} | ||
===human insulin degrading enzyme E111Q in complex with inhibitor compound 41367=== | ===human insulin degrading enzyme E111Q in complex with inhibitor compound 41367=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2ypu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2ypu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yb3 2yb3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YPU OCA]. | ||
[[Category: | |||
==See Also== | |||
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Human]] | |||
[[Category: Insulysin]] | [[Category: Insulysin]] | ||
[[Category: Deprez, B.]] | [[Category: Deprez, B.]] | ||