4o09: Difference between revisions

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OCA

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-'''Unreleased structure'''
+{{STRUCTURE_4o09|  PDB=4o09  |  SCENE=  }}
+===Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease===
+{{ABSTRACT_PUBMED_24673104}}
-The entry 4o09 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
-Authors: Zuccola, H.J., Ernst, J.T.
+==About this Structure==
+[[4o09]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O09 OCA].
-Description: Identification of novel HSP90 / isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington s disease
+==Reference==
+<ref group="xtra">PMID:024673104</ref><references group="xtra"/><references/>
+[[Category: Ernst, J T.]]
+[[Category: Zuccola, H J.]]
+[[Category: Chaperone]]
+[[Category: Chaperone-chaperone inhibitor complex]]