2m8j: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_2m8j|  PDB=2m8j  |  SCENE=  }}
+===Structure of Pin1 WW domain phospho-mimic S16E===
+{{ABSTRACT_PUBMED_23968199}}
-The entry 2m8j is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref>
-Authors: Luh, L.M., Kirchner, D.K., Loehr, F., Haensel, R., Doetsch, V.
+==About this Structure==
+[[2m8j]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M8J OCA].
-Description: Structure of Pin1 WW domain phospho-mimic S16E
+==Reference==
+<ref group="xtra">PMID:023968199</ref><references group="xtra"/><references/>
+[[Category: Peptidylprolyl isomerase]]
+[[Category: Doetsch, V.]]
+[[Category: Haensel, R.]]
+[[Category: Kirchner, D K.]]
+[[Category: Loehr, F.]]
+[[Category: Luh, L M.]]
+[[Category: Isomerase]]
+[[Category: Phospho mimic]]
+[[Category: Pin1]]
+[[Category: Ww domain]]