Sandbox reserved 915: Difference between revisions
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== Catalytic triad == | == Catalytic triad == | ||
MGL has a classic <scene name='58/580298/Catalytic_triad/1'>catalytic triad</scene> that contains Ser-His-Asp ('''figure 1'''). The triad was found using site-directed mutagenesis of each individual residue and each of these amino acid residues are catalytically essential to MGL <ref name="Bertrand" />. The catalytic triad is located in the binding pocket buried at the bottom of it in the oxyanion hole connected by a water molecule. [[Image:Catalytic_triad_binding_pocket.png|300px]] | MGL has a classic <scene name='58/580298/Catalytic_triad/1'>catalytic triad</scene> that contains Ser-His-Asp ('''figure 1'''). The triad was found using site-directed mutagenesis of each individual residue and each of these amino acid residues are catalytically essential to MGL <ref name="Bertrand" />. The catalytic triad is located in the binding pocket buried at the bottom of it in the oxyanion hole connected by a water molecule. | ||
[[Image:Catalytic_triad_binding_pocket.png|300px]] | |||
This triad has a natural attraction to Endocannabinoids, specifically 2-arachidonylglycerol (2-AG) <ref name="Bertrand" />. | This triad has a natural attraction to Endocannabinoids, specifically 2-arachidonylglycerol (2-AG) <ref name="Bertrand" />. | ||