Sandbox Reserved 921: Difference between revisions

The <scene name='57/573136/Starting_view/1'>surface</scene> of FAAH reveals two openings directly accessible by the inner layer of the lipid bilayer.  These <scene name='57/573136/Membrane_access_channel/4'>membrane access channels</scene> (MAC) are each proceed by a respective membrane binding cap.  This sturdy flap appears to be loosened by the presence of five positively charged residues, and the each MAC is remains conformation-stable by a salt bridge.  The membrane access channel leads to the active site, which is flanked by the both the <scene name='57/573136/Cytosolic_port/2'>acyl chain binding pocket and cytosolic port </scene> (ABP and CP).  The cytosolic port is a lengthy, flexible loop that leads directly into the cytoplasm, allowing the deacylated amine to enter the cell.