Sandbox Reserved 919: Difference between revisions

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OCA, Nathan Alexander Holt, Steven Han, Gregory Zemtsov, R. Jeremy Johnson

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 ==Introduction==
 [[Image:MGLProt.jpg|300 px|right|thumb|Monomer of MGL created in PYMOL (PDB:3PE6)]]
-'''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] enzyme that exhibits an [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold]. MGL possesses an amphipathic character, that allows the protein to be present both in the membrane and in the cytosol. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid produced by the the central nervous system. The α/β fold, along with a characteristic amphipathic occluded tunnel, allows 2-AG to selectively bind to the active site and be broken down into arachidonic acid and glycerol. Upon breakdown, glycerol leaves via an "exit tunnel" found perpendicular to the active site. 2-AG itself has been found to possess anti-nociceptive, immunomodulatory, anti-inflammatory and tumor-reductive character when it binds to cannabinoid receptors. Due to the vast medical and therapeutic utility of 2-AG, the inhibition of MGL is a high interest target in pharmaceutical research. <ref name="bert"> PMID:19962385 </ref>
+'''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] enzyme that exhibits an [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold]. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid produced by the the central nervous system. MGL possesses an amphipathic character, that allows the protein to be present both in the membrane and in the cytosol. The α/β fold, along with a characteristic amphipathic occluded tunnel, allows 2-AG to selectively bind to the active site and be broken down into arachidonic acid and glycerol. Upon breakdown, glycerol leaves via an "exit tunnel" found perpendicular to the active site. 2-AG itself has been found to possess anti-nociceptive, immunomodulatory, anti-inflammatory and tumor-reductive character when it binds to cannabinoid receptors. Due to the vast medical and therapeutic utility of 2-AG, the inhibition of MGL is a high interest target in pharmaceutical research. <ref name="bert"> PMID:19962385 </ref>
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