Sandbox Reserved 919: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[Image:MGLProt.jpg|300 px|right|thumb|Monomer of MGL created in PYMOL (PDB:3PE6)]] | [[Image:MGLProt.jpg|300 px|right|thumb|Monomer of MGL created in PYMOL (PDB:3PE6)]] | ||
'''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] enzyme that exhibits an [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold]. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid produced by the the central nervous system | '''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] enzyme that exhibits an [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold]. In addition, MGL possesses amphitropic character, where the area around the active site of MGL is polar while the site itself is non-polar. This characteristic allows the protein to be present both in the membrane and in the cytosol. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid produced by the the central nervous system. The α/β fold allows 2-AG to selectively bind to the active site and be broken down into arachidonic acid and glycerol. Upon breakdown, glycerol leaves via an "exit tunnel" found perpendicular to the α/β fold. 2-AG itself has been found to possess anti-nociceptive, immunomodulatory, anti-inflammatory and tumor-reductive character when it binds to cannabinoid receptors. Due to the vast medical and therapeutic utility of 2-AG, the inhibition of MGL is a high interest target in pharmaceutical research. <ref> PMID:19962385 </ref> | ||
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<scene name='57/573133/Ligand_showing/1'>Ligand Bound</scene> | <scene name='57/573133/Ligand_showing/1'>Ligand Bound</scene> | ||
<p><scene name='57/573134/Catalytic_triad/2'>Catalytic Triad</scene></p> | <p><scene name='57/573134/Catalytic_triad/2'>Catalytic Triad</scene></p> | ||
<p><scene name='57/573134/Oxyanion_hole/1'>Oxyanion Hole</scene></p> | |||
</StructureSection> | </StructureSection> | ||