4jq1: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jq1|  PDB=4jq1  |  SCENE=  }}
+===AKR1C2 complex with naproxen===
-The entry 4jq1 is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Defects in AKR1C2 are a cause of 46,XY sex reversal type 8 (SRXY8) [MIM:[http://omim.org/entry/614279 614279]]. A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.<ref>PMID:21802064</ref>
-Authors: Yosaatmadja, Y, Flanagan, J.U., Squire, C.J
+==Function==
+[[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.<ref>PMID:8573067</ref>
-Description: AKR1C2 complex with naproxen
+==About this Structure==
+[[4jq1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQ1 OCA].
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Flanagan, J U.]]
+[[Category: Squire, C J]]
+[[Category: Yosaatmadja, Y]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]