4ogt: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4ogt|  PDB=4ogt  |  SCENE=  }}
+===Co-Crystal Structure of MDM2 with Inhbitor Compound 46===
+{{ABSTRACT_PUBMED_24601644}}
-The entry 4ogt is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] Note=Seems to be amplified in certain tumors (including soft tissue sarcomas, osteosarcomas and gliomas). A higher frequency of splice variants lacking p53 binding domain sequences was found in late-stage and high-grade ovarian and bladder carcinomas. Four of the splice variants show loss of p53 binding.
-Authors: Shaffer, P.L., Huang, X., Yakowec, P., Long, A.M.
+==Function==
+[[http://www.uniprot.org/uniprot/MDM2_HUMAN MDM2_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and promotes it to proteasomal degradation.<ref>PMID:12821780</ref> <ref>PMID:15053880</ref> <ref>PMID:15195100</ref> <ref>PMID:16337594</ref> <ref>PMID:15632057</ref> <ref>PMID:17290220</ref> <ref>PMID:19098711</ref> <ref>PMID:19219073</ref> <ref>PMID:19965871</ref> <ref>PMID:20858735</ref> <ref>PMID:20173098</ref>
-Description: Co-Crystal Structure of MDM2 with Inhbitor Compound 46
+==About this Structure==
+[[4ogt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OGT OCA].
+==Reference==
+<ref group="xtra">PMID:024601644</ref><references group="xtra"/><references/>
+[[Category: Huang, X.]]
+[[Category: Long, A M.]]
+[[Category: Shaffer, P L.]]
+[[Category: Yakowec, P.]]
+[[Category: Ligase-ligase inhibitor complex]]
+[[Category: P53]]
+[[Category: Protein-protein interaction]]