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<big>''Here's an excerpt from one of our pages:''</big> | <big>''Here's an excerpt from one of our pages:''</big> | ||
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><font color='green'>indirectly via solvent molecules</font></b>. | The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><span onClick='getJava();'><font color='green' >indirectly via solvent molecules</font></span></b>. | ||
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You will find in this [[Proteopedia:Troubleshooting|Troubleshooting]] page help for enabling Java in your computer and start enjoying Proteopedia's features. | You will find in this [[Proteopedia:Troubleshooting|Troubleshooting]] page help for enabling Java in your computer and start enjoying Proteopedia's features. | ||
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Revision as of 10:05, 24 February 2008
Welcome to Proteopedia,
The collaborative, 3D encyclopedia of proteins and other molecules.
Green links change the 3D image!Green links change the 3D image!
Here's an excerpt from one of our pages:
The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from Torpedo california) complex shows that E2020 has a unique orientation along the active-site gorge, extending from the anionic subsite (W84) of the active site, at the bottom, to the peripheral anionic site (near W279), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only indirectly via solvent molecules.
This is a static page!!. Java is required in order to view the 3D molecules in Proteopedia.
You've been referred to this page because your computer is most likely missing Java. You will find in this Troubleshooting page help for enabling Java in your computer and start enjoying Proteopedia's features.