2dko: Difference between revisions
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{{STRUCTURE_2dko| PDB=2dko | SCENE= }} | {{STRUCTURE_2dko| PDB=2dko | SCENE= }} | ||
===Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis=== | ===Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis=== | ||
{{ABSTRACT_PUBMED_16787777}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[2dko]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[2dko]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DKO OCA]. | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 13: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016787777</ref><references group="xtra"/> | <ref group="xtra">PMID:016787777</ref><references group="xtra"/><references/> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Ganesan, R.]] | [[Category: Ganesan, R.]] | ||
[[Category: Grutter, M G.]] | [[Category: Grutter, M G.]] | ||
Revision as of 10:17, 2 April 2014
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysisExtended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Template:ABSTRACT PUBMED 16787777
FunctionFunction
[CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.[1] [2]
About this StructureAbout this Structure
2dko is a 3 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Ganesan R, Mittl PR, Jelakovic S, Grutter MG. Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J Mol Biol. 2006 Jun 23;359(5):1378-88. Epub 2006 May 11. PMID:16787777 doi:10.1016/j.jmb.2006.04.051
- ↑ Nicholson DW, Ali A, Thornberry NA, Vaillancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, et al.. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995 Jul 6;376(6535):37-43. PMID:7596430 doi:http://dx.doi.org/10.1038/376037a0
- ↑ Cabrera JR, Bouzas-Rodriguez J, Tauszig-Delamasure S, Mehlen P. RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem. 2011 Apr 22;286(16):14628-38. doi: 10.1074/jbc.M110.195461. Epub, 2011 Feb 28. PMID:21357690 doi:10.1074/jbc.M110.195461