4n95: Difference between revisions
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{{STRUCTURE_4n95| PDB=4n95 | SCENE= }} | {{STRUCTURE_4n95| PDB=4n95 | SCENE= }} | ||
===E. coli sliding clamp in complex with 5-chloroindoline-2,3-dione=== | ===E. coli sliding clamp in complex with 5-chloroindoline-2,3-dione=== | ||
{{ABSTRACT_PUBMED_24592885}} | |||
==Function== | ==Function== | ||
| Line 6: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
[[4n95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4n95]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N95 OCA]. | ||
==See Also== | |||
*[[DNA polymerase|DNA polymerase]] | |||
==Reference== | |||
<ref group="xtra">PMID:024592885</ref><references group="xtra"/><references/> | |||
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
[[Category: | [[Category: Ecoli]] | ||
[[Category: Oakley, A J.]] | [[Category: Oakley, A J.]] | ||
[[Category: Yin, Z.]] | [[Category: Yin, Z.]] | ||
Revision as of 10:16, 2 April 2014
E. coli sliding clamp in complex with 5-chloroindoline-2,3-dioneE. coli sliding clamp in complex with 5-chloroindoline-2,3-dione
Template:ABSTRACT PUBMED 24592885
FunctionFunction
[DPO3B_ECOLI] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA.
About this StructureAbout this Structure
4n95 is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Yin Z, Whittell LR, Wang Y, Jergic S, Liu M, Harry EJ, Dixon NE, Beck JL, Kelso MJ, Oakley AJ. Discovery of lead compounds targeting the bacterial sliding clamp using a fragment-based approach. J Med Chem. 2014 Mar 27;57(6):2799-806. doi: 10.1021/jm500122r. Epub 2014 Mar 18. PMID:24592885 doi:http://dx.doi.org/10.1021/jm500122r