4m0f: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4m0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4m0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M0F OCA]. | ||
==See Also== | |||
*[[Acetylcholinesterase|Acetylcholinesterase]] | |||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <references group="xtra"/><references/> | ||
[[Category: Acetylcholinesterase]] | [[Category: Acetylcholinesterase]] | ||
[[Category: | [[Category: Human]] | ||
[[Category: Cheung, J.]] | [[Category: Cheung, J.]] | ||
[[Category: Gary, E N.]] | [[Category: Gary, E N.]] | ||
Revision as of 10:12, 2 April 2014
Structure of human acetylcholinesterase in complex with territrem BStructure of human acetylcholinesterase in complex with territrem B
FunctionFunction
[ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.[1] [2] [3] [4]
About this StructureAbout this Structure
4m0f is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Chhajlani V, Derr D, Earles B, Schmell E, August T. Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. FEBS Lett. 1989 Apr 24;247(2):279-82. PMID:2714437
- ↑ Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, Flashner Y, Marcus D, Cohen S, Shafferman A. The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem. 1991 Dec 15;266(35):23977-84. PMID:1748670
- ↑ Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel N, Barak D, et al.. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem. 1992 Sep 5;267(25):17640-8. PMID:1517212
- ↑ Yang L, He HY, Zhang XJ. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res. 2002 Apr;42(4):261-8. PMID:11985878