Pantothenate kinase: Difference between revisions
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==3D structures of pantothenate kinase== | ==3D structures of pantothenate kinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br /> | [[1esm]] – EcPanK + CoA – ''Escherichia coli''<br /> | ||
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[[2zsd]] - MtPanK + CoA<br /> | [[2zsd]] - MtPanK + CoA<br /> | ||
[[3avo]] - MtPanK + PAU<br /> | [[3avo]] - MtPanK + PAU<br /> | ||
[[3avp]], [[3avq]] - MtPanK + PAU derivative | [[3avp]], [[3avq]] - MtPanK + PAU derivative<br /> | ||
[[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br /> | |||
[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br /> | |||
==PanK I ternary complex== | ==PanK I ternary complex== | ||
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[[3aez]] - MtPanK + GDP + PPT<BR /> | [[3aez]] - MtPanK + GDP + PPT<BR /> | ||
[[3af0]] - MtPanK + GDP + PAU<br /> | [[3af0]] - MtPanK + GDP + PAU<br /> | ||
[[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br /> | |||
[[4gi7]] – KpPanK + ADP + pantothenate analog<br /> | |||
===PanK II=== | ===PanK II=== | ||
[[2ews]] - | [[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> | ||
[[4nb4]] - SaPanK + ADP + pantothenamide<br /> | |||
===PanK III=== | ===PanK III=== | ||
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[[2h3g]] - PanK – ''Bacillus anthracis''<br /> | [[2h3g]] - PanK – ''Bacillus anthracis''<br /> | ||
[[3djc]] - PanK – ''Legionella pneumophila''<br /> | [[3djc]] - PanK – ''Legionella pneumophila''<br /> | ||
[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br /> | |||
==PanK III binary complex== | ==PanK III binary complex== | ||
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[[3bf1]] - TmPanK + ADP + PAU<br /> | [[3bf1]] - TmPanK + ADP + PAU<br /> | ||
[[4o5f]] - BtPanK + ADP + PAU <br /> | |||
===Human PanK=== | ===Human PanK=== | ||
Revision as of 09:10, 2 April 2014
Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.
3D structures of pantothenate kinase3D structures of pantothenate kinase
Updated on 02-April-2014
1esm – EcPanK + CoA – Escherichia coli
1esn - EcPanK + ANP
1sq5 - EcPanK + ADP + PAU
3tqc - PanK – Coxiella burnetii
PanK I binary complexPanK I binary complex
2ges, 2get, 2zs7, 2geu, 2gev - MtPanK + CoA derivative – Mycobacterium tuberculosis
2zs8, 2zsb - MtPanK + ADP
3af1 - MtPanK + GDP
3af2 - MtPanK + AMPPCP
3af4 - MtPanK + GMPPCP
2zsd - MtPanK + CoA
3avo - MtPanK + PAU
3avp, 3avq - MtPanK + PAU derivative
4bfs, 4bft, 4bfu, 4bfv, 4bfw, 4bfx - MtPanK + triazole inhibitor
4bfy, 4bfz - MtPanK + biaryl inhibitor
PanK I ternary complexPanK I ternary complex
2zs9 - MtPanK + ADP + PAU
2zse - MtPanK + AMPPCP + PAU
3af3 - MtPanK + GMPPCP + PAU
2zsf - MtPanK + ADP + ATP
2zsa - MtPanK + ADP + PPT
3aez - MtPanK + GDP + PPT
3af0 - MtPanK + GDP + PAU
4f7w, 4ne2 – KpPanK + ADP + pantothenamide derivative – Klebsiella pneumonia
4gi7 – KpPanK + ADP + pantothenate analog
PanK IIPanK II
2ews - SaPanK + ANP – Staphylococcus aureus
4nb4 - SaPanK + ADP + pantothenamide
PanK IIIPanK III
2gtd - TmPanK – Thermotoga maritima
2f9t – PaPanK – Pseudomonas aeruginosa
2h3g - PanK – Bacillus anthracis
3djc - PanK – Legionella pneumophila
4o8k - BtPanK – Burkholderia thailandensis
PanK III binary complexPanK III binary complex
2f9w - PaPanK + PAU
3bex - TmPanK + PAU
3bf3 - TmPanK + PPT
PanK III ternary complexPanK III ternary complex
3bf1 - TmPanK + ADP + PAU
4o5f - BtPanK + ADP + PAU
Human PanKHuman PanK
2i7n, 3smp - hPanK 1 α + CoA - human
2i7p, 3mk6 - hPanK 3 + CoA
3sms – hPanK 3 + PAU analog