Sandbox Reserved 914: Difference between revisions
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=== Catalytic Triad === | === Catalytic Triad === | ||
The <scene name='57/573128/2/1'>catalytic triad</scene> is composed of Ser115, His289, and Asp233, which is the same as the catalytic triad in chymotrypsin. | The <scene name='57/573128/2/1'>catalytic triad</scene> is composed of Ser115, His289, and Asp233, which is the same as the catalytic triad in chymotrypsin. | ||
A water molecule is occupying the <scene name='57/573128/7/1'>oxyanion hole</scene> and it is hydrogen bonded to Ser115. | A water molecule is occupying the <scene name='57/573128/7/1'>oxyanion hole</scene> and it is hydrogen bonded to Ser115. The purpose of the oxyanion hole is to stabilize the oxyanion that is formed after the nucleophilic attack, which happens to be in the transition state. Ser115 acts as a nucleophile, while His289 and Asp233 are coordinated to Ser115 to lower its pKa value so it can undergo catalytic activity. | ||
===Hydrophobic Groove === | ===Hydrophobic Groove === | ||